#Anaphylaxis and Angioedema

## Angioedema

![alt](https://photos.collectednotes.com/photos/5187/06657f72-c3be-4130-92cb-80b80b2a67d5)

Dermal, SQ, mucosal swelling - non pitting. vasodilation and increased vascular permeability.

24-72 hour course

- idiopathic
- associated with allergic and non-allergic reactions due to antigens (e.g. venom, drugs, foods, pathogens, animals, latex(
- C1-INH deficiency: inherited or acquired 

![alt](https://photos.collectednotes.com/photos/5187/571cbeb7-2efd-4a67-9fcc-56d8c7230ba0)

#### Drugs
https://www.sciencedirect.com/science/article/pii/S1323893015302550?via%3Dihub

![alt](https://photos.collectednotes.com/photos/5187/289b7162-b87f-4d79-a3e4-a50195069876)

~50 % associated with urticartia

- ACEi:  never associated with urticaria
- NSAID: non allergic 
![alt](https://photos.collectednotes.com/photos/5187/66fdd152-802d-4008-a594-4bc42a33ab34)

- Antibiotics (particularly beta-lactam)


### Management 
![alt](https://photos.collectednotes.com/photos/5187/44e19f57-acc7-4a53-9b73-f5f64ee961b2)


## Anaphylaxis

![alt](https://photos.collectednotes.com/photos/5187/f76275de-2577-48e0-bfa5-183952d7f84e)

![alt](https://photos.collectednotes.com/photos/5187/ef6e62b0-dc13-4866-abed-8284d39d790d)

![alt](https://photos.collectednotes.com/photos/5187/67450424-d1fc-4308-8602-87f1b54ea638)# Angioedema and Anaphylaxis